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教育部重点实验室夏成峰团队在基于有机负离子的可见光反应取得系列进展2021年10月28日
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云南大学羊晓东/张洪彬团队在不饱和胺的合成领域取得研究进展2021年07月07日
不饱和胺，特别是烯丙基胺、高烯丙基胺，是众多天然产物、药物分子及生物活性分子中的重要基本结构单元。同时，不饱和胺是重要的合成中间体，可以参与一系列有机化学及药物化学领域的合成转化。因此，长期以来不饱和胺结构单元的合成策略研究引起了国内外研究者的高度重视。 近期，云南大学自然资源药物化学教育部重点实验室羊晓东教授/张洪彬教授团队开展合作研究，在不饱和胺类的合成领取得了研究进展。该团队发展了一系列...
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云南大学肖伟烈团队合作发表天然产物治疗肝癌的研究成果2021年06月22日
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重点实验室林军、金毅团队研发的术后镇痛药获国家食品药品监督管理总局生产批件2021年05月19日
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Cu-Catalyzed Direct Amination of Cyclic Amides via C−OH Bond Activation Using DMF2020年08月12日
Cu-Catalyzed Direct Amination of Cyclic Amides via C–OH Bond Activation Using DMFBy: Peng Chen, Kaixiu Luo, Xianglin Yu, Xu Yuan, Xiaoyu Liu, Jun Lin*, and Yi Jin*Organic Letters, 2020,onlineDOI: 10.1021/acs.orglett.0c02320Publication Date: August 11, 2020AbstractHerein, we describe a Cu-catalyzed approach to directly accessing aromatic heterocyclic amines from cyclic amides. The most-reported...
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Silver-catalyzed cascade reactions of 3-cyanochromone with 1,1-enediamines: synthesis of highly functionalized 2-(pyridin-3-yl)chromeno[2,3-d]pyrimidines2020年06月30日
Silver-catalyzed cascade reactions of 3-cyanochromone with 1,1-enediamines: synthesis of highly functionalized 2-(pyridin-3-yl)chromeno[2,3-d]pyrimidinesBy: Qiang Xiao,‡ Jin Liu,‡ Jia-Hui Nie, Ling-Bin Kong, Jun Lin * and Sheng-Jiao Yan *Organic Chemistry Frontiers 2020, 7, 2035-2039DOI: 10.1039/d0qo00388cPublication Date: 17 Jun 2020AbstractA novel protocol for the construction of highly fun...
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Cascade reaction of isatins with nitro-substituted enamines: highly selective synthesis of functionalized (Z)-3-(1-(arylamino)-2oxoarylidene)indolin-2-ones2020年04月15日
Cascade reaction of isatins with nitro-substituted enamines: highly selective synthesis of functionalized (Z)-3-(1-(arylamino)-2oxoarylidene)indolin-2-onesBy: Cong-Hai Zhang, Rong Huang, Xia Qing, Jun Lin * and Sheng-Jiao Yan *Chemical Communications 2020,56,3488DOI: 10.1039/d0cc00923gPublication Date: 2nd March 2020AbstractA novel protocol for the construction of functionalized (Z)-3(1(-arylam...
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【论文发表】Discovery of arylamide-5-anilinoquinazoline-8-nitro derivatives as VEGFR-2 kinase inhibitors: synthesis, in vitro biological evaluation and molecular docking2019年10月21日
Discovery of arylamide-5-anilinoquinazoline-8-nitro derivatives as VEGFR-2 kinase inhibitors: synthesis, in vitro biological evaluation and molecular dockingBy: Yongqiang Zhao, Feifei Liu, Guojing He, Ke Li, Changcheng Zhu, Wei Yu, Conghai Zhang, Mingjin Xie, Jun Lin, Jihong Zhang, Yi JinKey Laboratory of Medicinal Chemistry for Natural Resource, Ministry Education and Yunnan Province, School o...
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【论文发表】Tandem reaction of heterocyclic ketene aminals with diazoesters: Synthesis of pyrimidopyrrolidone derivatives2019年09月30日
Tandem reaction of heterocyclic ketene aminals with diazoesters: Synthesis of pyrimidopyrrolidone derivativesBy: Kaixiu Luo, Weina Li, Jun Lin, Yi JinKey Laboratory of Medicinal Chemistry for Natural Resource, Ministry Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, P. R. ChinaTetrahedron Letters 60 (2019) 151136doi.org/10.1016/j.tet...
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【论文发表】Synthesis and antitumor activity of aza-brazilan derivatives containing imidazolium salt pharmacophores 2019年09月10日
Synthesis and antitumor activity of aza-brazilan derivatives containing imidazolium salt pharmacophores By: Huang, Mingqin; Duan, Shengzu; Ma, Xueqiong; Cai, Bicheng; Wu, Dongmei; Li, Yan; Li, Liang; Zhang, Hongbin; Yang, Xiaodong MEDCHEMCOMM Volume: 10 Issue: 6 Pages: 1027-1036 DOI: 10.1039/c9md00112c Published: JUN 1 2019 Document Type:ArticleAbstractThe synthesis of a series of novel aza-bra...
