Synthesis of Aminoalkyl Nitriles through 2-Azaallyl Anions-Driven Cascade Radical Ring-Opening/Intermolecular Coupling By: Yonggang Jiang; Cuirong Qin; Haoqing Tang; Liang Li; Hongbin Zhang; Xiaodong YangOrganic Chemistry Frontiers DIO: https://doi.org/10.1039/D5QO01353D Published：2025-10-16 Abstract Aminoalkyl nitriles are common structural motifs in bioactive molecules and they serve as val...

 Nickel-Catalyzed Regio- and Enantioselective Hydroalkenylation of Aldehydes with 2Azadienes By: Ya Du; Lening Zhang; Shengzu Duan; Xiang Yang; Sina Liu; Hongbin Zhang; Patrick J. Walsh; Xiaodong Yang Journal of the American Chemical Society DIO: https://doi.org/10.1021/jacs.5c08602Published：2025-08-07 AbstractThe development of new methods for the utilization of aldehydes has garnered much a...

 Coupling of Acyl Radical Precursors with 2-Azaallyl Anions for the Synthesis of α-Amino Ketones By: Haitao Yang; Yu Pan; Canli Zhang; Chen Chen; HaoqinTang; HongbinZhang; Guogang Deng; Xiaodong YangOrganic LettersDIO: https://doi.org/10.1021/acs.orglett.5c01295Published：2025-05-01AbstractA novel transition-metal-free radical coupling of 2-azaallyl anions for the synthesis of α-amino ketones...

Benzylic C(sp3)–H/C(sp3)–H Coupling with 2-Azaallyl Anions through Single-Electron Transfer and 1,5-Hydrogen Atom Transfer By: Dongxiang Liu; Bijun Wang; Cuirong Qin; Haoqing Tang; Hui Li, Liang Li; Yonggang Jiang; Xiaodong YangOrganic Letters DIO: https://doi.org/10.1021/acs.orglett.5c00708 Published：2025-03-20 Abstract Herein is reported a novel transition-metal-free intermolecular C(sp3)...

 Enantioselective Synthesis of Vicinal Diamines and β-Amino Amides by NiH-Catalyzed Hydroamidation of Alkenyl amidesBy:Xun Tian; Shengzu Duan; Yuan Ma; Ailin Pan; Yamiao Meng; Guogang Deng; Hongbin Zhang; Xiaodong YangOrganic Chemistry FrontiersDIO: https://doi.org/10.1039/D4QO02275KPublished：2025-01-19AbstractEnantioenriched diamines and β-amino amides are privileged scaffolds in organic an...

Enantioselective Synthesis of Aminals via Nickel-Catalyzed Hydroamination of 2-Azadienes with Indoles and N-HeterocyclesBy:Du, Ya ; Duan, Shengzu; Huang, Shuntao; Liu, Tongqi; Zhang, Hongbin; Walsh, Patrick J; Yang, XiaodongJournal of the American Chemical SocietyDOI：https://doi.org/10.1021/jacs.4c09750Published：2024-10-30AbstractNew methods for the enantioselective synthesis of N-alkylated i...

      Stereoselective Construction of Multifunctional C-Glycosides Enabled by Nickel-Catalyzed Tandem Borylation/GlycosylationBy:Wu，Xiaomei；Li，Shijia ；Chen，Liqin ；Ma，Siwei ；Ma，Bin ；Song，Lijuan ；Qian，DeyunJournal of the American Chemical SocietyDOI：https://doi.org/10.1021/jacs.4c05485Published：2024-08-03Abstract      Stereochemically pure saccharides have indispensable roles in fi...

      Deuteration of arenes in pharmaceuticals via photoinduced solvated electronsBy:Yi Tao；Cuihua Jin；Chuanwang Liu；Jiawei Bu； Ling Yue； Xipan Li；Kangjiang Liang；Chengfeng XiaChemDOI：https://doi.org/10.1016/.chempr.2024.06.029Published：2024-07-18Abstract      Deuterium incorporation into pharmaceutical molecules has been recognized as having a positive impact on drug efficacy and safe...

Bithiophene-Functionalized Infrared Two-Photon Absorption Metal Complexes as Single-Molecule Platforms for Synergistic Photodynamic, Photothermal, and ChemotherapyBy:Li, Xue-Lian ; Wang, Meng-Fan ;  Zeng, Li-Zhen ; Li, Guo-Kui ; Zhao, Run-Yu ; Liu, Fu-Dan ; Li, Yun ; Yan, Yu-Fei ; Liu, Qishuai ; Li, Zhao ; Zhang, Hongbin ; Ren, Xiaoxia ; Gao, FengAngewandte Chemie - International EditionDOI：ht...

Protoilludane-Type and Related Nor-Sesquiterpenes from Phellinus hartigii and Their Anti-Hypertrophic Activities in Rat CardiomyocytesBy: Quan Fu, Jing Yuan, Tie-Hua Yang, Jin-Hao Su, Jing-Jing Zhang, Xue-Wen Wu, Hong-Ye Zhang, Wei-Lie Xiao, Chang-Bo Zheng, and Xiao-Li LiJournal of Natural ProductsDOI：https://doi.org/10.1021/acs.jnatprod.3c00985Published：2024-02-03AbstractThree nor-sesquiterp...