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Visible and Near-Infrared Photopharmacology:Wavelength-Redshift Strategies for Spatiotemporally Precise Therapeutics By:Wang, Lei；Wu, Ying；Tan, Xiangqian； Xia, ChengfengJournal of Medicinal ChemistryDOI：https://doi.org/10.1021/acs.jmedchem.5c02041 Published：2026-01-20AbstractPhotopharmacology is an innovative paradigm for spatiotemporally controlled drug activity, offering a novel approach...
Palladium-Catalysed Aminocarbonylation of Aryl Thianthrenium Salts to Aryl Carboxamides Using Mo(CO)6 as a CO SourceBy: Zhuo Chen, Hui-Qiang Li, Shun-Bin Xu, Ling-Rui Zhou, Tong-Ling Qin, Wen-Xia Hu, Tao Li, Ruo-Yi Hou, Zi-Yu Lin and E TangOrganic Chemistry Frontiers DIO: 10.1039/d5qo01508aPublished：2025-12-30Abstract An efficient palladium-catalysed aminocarbonylation reaction between aryl th...
By：Ma, Xiurong;Wang, Guixi; Zhou, Qian; Liu, Yanxiong; He, Runying; Xie, Zuoxun; Shi, Yonggang; Cao, Qiue; Zheng, LiyanJournal of Medicinal ChemistryDOI：https://doi.org/10.1021/acs.jmedchem.5c02006Published：2025-11-13AbstractThe development of a photosensitizer (PS) integrating real-time therapeutic monitoring capability represents a critical advancement in precision photodynamic therapy (P...
Synthesis of Aminoalkyl Nitriles through 2-Azaallyl Anions-Driven Cascade Radical Ring-Opening/Intermolecular Coupling By: Yonggang Jiang; Cuirong Qin; Haoqing Tang; Liang Li; Hongbin Zhang; Xiaodong YangOrganic Chemistry Frontiers DIO: https://doi.org/10.1039/D5QO01353D Published：2025-10-16 Abstract Aminoalkyl nitriles are common structural motifs in bioactive molecules and they serve as val...
Nonemissive Ruthenium Complexes for Near Infrared-II Photodynamic, Photothermal, Sonodynamic, and Sonothermal Therapy Against Drug-Resistant CancerBy：Song, Ran；Zhao, Run-Yu；Yan, Ru；Li, Xue-Lian；Zeng, Li-Zhen；Cai,Zhongyan；Chen, Jingbo；Ren, Xiaoxia；Cheng, Xiaohong； Gao, FengJournal of Medicinal ChemistryDOI：https://doi.org/10.1021/acs.jmedchem.5c01371 Published：2025-08-28AbstractNine ...
Nickel-Catalyzed Regio- and Enantioselective Hydroalkenylation of Aldehydes with 2-Azadienes By: Ya Du; Lening Zhang; Shengzu Duan; Xiang Yang; Sina Liu; Hongbin Zhang; Patrick J. Walsh; Xiaodong Yang Journal of the American Chemical Society DIO: https://doi.org/10.1021/jacs.5c08602Published：2025-08-07 AbstractThe development of new methods for the utilization of aldehydes has garnered much a...
Design, Synthesis, and Biological Evaluation of Novel Activators of Human Caseinolytic Protease P with a Pyrazololactam ScaffoldBy：Tang, Rui；Li, Qiannan；Zhou, Heyang；Li, Yu；Li, Tong；; Jiang, Jinxin；Chen, Ziyuan；Kong, Lingmei；Li, Yan；Xiao, Yibei；Sun, HaiyingJournal of Medicinal ChemistryDOI：https://doi.org/10.1021/acs.jmedchem.4c03000Published：2025-05-03AbstractBased on D9, a previo...
Coupling of Acyl Radical Precursors with 2-Azaallyl Anions for the Synthesis of α-Amino Ketones By: Haitao Yang; Yu Pan; Canli Zhang; Chen Chen; HaoqinTang; HongbinZhang; Guogang Deng; Xiaodong YangOrganic LettersDIO: https://doi.org/10.1021/acs.orglett.5c01295Published：2025-05-01AbstractA novel transition-metal-free radical coupling of 2-azaallyl anions for the synthesis of α-amino ketones...
Benzylic C(sp3)–H/C(sp3)–H Coupling with 2-Azaallyl Anions through Single-Electron Transfer and 1,5-Hydrogen Atom Transfer By: Dongxiang Liu; Bijun Wang; Cuirong Qin; Haoqing Tang; Hui Li, Liang Li; Yonggang Jiang; Xiaodong YangOrganic Letters DIO: https://doi.org/10.1021/acs.orglett.5c00708 Published：2025-03-20 Abstract Herein is reported a novel transition-metal-free intermolecular C(sp3)...