Tandem reaction of heterocyclic ketene aminals with diazoesters: Synthesis of pyrimidopyrrolidone derivatives
By: Kaixiu Luo, Weina Li, Jun Lin, Yi Jin
Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, P. R. China
Tetrahedron Letters 60 (2019) 151136
doi.org/10.1016/j.tetlet.2019.151136
Publication Date (Web): September 10, 2019
Document Type: Article
Abstract
A tandem reaction of heterocyclic ketene aminals (HKAs) with diazoesters in the presence of a Cu catalyst is demonstrated for the efficient synthesis of pyrimidopyrrolidone derivatives. The reaction shows a broad substrate scope and excellent functional group tolerance. Our method provides rapid access to diverse pyrimidopyrrolidones in moderate to excellent yields under mild reaction conditions.
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https://www.sciencedirect.com/science/article/pii/S0040403919309049