Efficient construction of functionalized pyrroloindolines through cascade radical cyclization/intermolecular couplingBy:Jiang, Yonggang ; Liu, Dongxiang; Zhang, Lening ; Qin, Cuirong; Li, Hui; Yang, Haitao ; Walsh, Patrick J. ; Yang, Xiaodong      Chemical ScienceDOI：https://doi.org/10.1039/d3sc05210aPublished：2024-02-07Abstract      Pyrroloindolines are important structural units in nature a...

β-carboline derivative Z86 attenuates colorectal cancer cell proliferation and migration by directly targeting PI3KBy: Shiyun Nie, Lizhong Chang, Ying Huang, Heyang Zhou, Qianqing Yang, Lingmei Kong & Yan LiNatural Products and BioprospectingDOI：https://doi.org/10.1007/s13659-023-00422-yPublished：2024-01-13AbstractPhosphoinositide 3-kinase (PI3Ks) are lipid kinases widely involved in cell pr...

Alisol B blocks the development of HFD-induced obesity by triggering the LKB1-AMPK signaling in subcutaneous adipose tissueBy: Ling Yang, Linzi Li, Qian Lu, Lingfeng Li, Chun Xie, Fakun Jiang, Hongbing Li, Ai Zhao, Qian Wang, Wenyong XiongEuropean Journal of PharmacologyDOI：https://doi.org/10.1016/j.ejphar.2023.175942Published：2023-10-05AbstractAs a global epidemic disease, obesity causes dys...

Iridium(III)-Based Infrared Two-Photon Photosensitizers: Systematic Regulation of Their Photodynamic Therapy EfficacyBy: Xue-Lian Li, Li-Zhen Zeng, Rong Yang, Xu-Dan Bi, Yang Zhang, Ruo-Bing Cui, Xin-Xi Wu, Feng GaoInorganic ChemistryDOI：https://doi.org/10.1021/acs.inorgchem.3c02364Published：2023-09-17AbstractCyclometalated iridium(III) complexes are of significant importance in the field of ...

Diverse diterpenoids from Callicarpa rubella Lindl. as natural inhibitors of macrophage foam cell formationBy: Xue-Wen Wu, Qian-Lang Feng, Yi-Fan Xie, Si-Chen Song, Bin Cheng, Yan Ma, Qing Li, Xu Ji, Xiao-Li Li, Guang Cao, Wei-Lie XiaoPhytochemistryDOI：https://doi.org/10.1016/j.phytochem.2023.113748Published：2023-JUNAbstractTen undescribed diterpenoids namely rubellawus E-N of structural type...

Challenges and opportunities for improving the druggability of natural product: Why need drug delivery system?By:Peng Tang, Tianze Shen, Hairong Wang, Ruihan Zhang, Xingjie Zhang, Xiaoli Li, Weilie XiaoBiomedicine & PharmacotherapyDOI：https://doi.org/10.1016/j.biopha.2023.114955Published：2023-AugAbstractBioactive natural products (BNPs) are the marrow of medicinal plants, which are the second...

FeCl3-catalyzed oxidative amidation of benzylic C-H bonds enabled by a photogenerated chlorine-radicalBy: Yingying Yang, Xianglin Yu, Na He, Xinxiang Huang, Xizhong Song, Jingbo Chen, Jun Lin and Yi JinChemical CommunicationsDOI：https://doi.org/10.1039/d3cc03186aPublished：2023-July-27AbstractHerein, we report the development of iron-catalyzed benzylic C-H oxidative amidation reactions via pho...

Methylene-Bridged Dimerization by Cu-Catalyzed Deconstructive C–C Cleavage of OxacycloalkaneBy: Xu Yuan, Jimei Yang, Xingjiang Yang, Na He, Mingyuan Han, Jun Lin, Wei Yu, Xiaohong Cheng, and Yi JinOrganic LettersDOI：https://doi.org/10.1021/acs.orglett.3c02015Published：2023-July-20AbstractHerein, we demonstrate the successful utilization of copper catalysis and oxygen oxidation for consecutiv...

Net-1,2-Hydrogen Atom Transfer of Amidyl Radicals: Toward the Synthesis of 1,2-Diamine DerivativesBy:Yonggang Jiang, Dongxiang Liu, Madeline E. Rotella, Guogang Deng, Zhengfen Liu, Wen Chen, Hongbin Zhang, Marisa C. Kozlowski, Patrick J. Walsh, and Xiaodong YangJournal of the American Chemical SocietyDOI：https://doi.org/10.1021/jacs.3c04376Published：2023-July-13AbstractHydrogenatom transfer (...

Identification and screening of novel diterpenoids from roasted arabica coffee in the regulation of lipid content in white adipocytesBy:Wang, Qian; Hu, Guilin;Lu, Qian; Hong, Defu; Al-Romaima, Abdulbaset;Qiu, Minghua; Xiong, WenyongFood & FunctionDOI：https://doi.org/10.1039/d3fo01130ePublished：2023-Jun-6AbstractPrevious studies have shown that coffee has a role in regulating lipid metabolism....