雷祖海
邮箱：lei_zuhai@fudan.edu.cn
职称：教授（博士生导师）
地址：云南大学呈贡校区药学院，国家重点实验室1栋1121
课题组主页：https://www.x-mol.com/groups/Lei_zuhai
教育经历
2012.09-2017.6，华东理工大学，药学，博士
2008.09-2012.06，华东理工大学，制药工程，学士
工作经历
2024.03-至今， 云南大学，药学院，教育部自然资源药物化学重点实验室，教授
2020.03-2024.03，复旦大学，药学院，青年研究员(博士生导师)
2018.01-2020.02，复旦大学，化学系，博士后
2017.06-2017.12，上海药明康德新药开发有限公司，高级研究员
研究领域
1. 开发用于生物医学应用的高性能长波长荧光染料，小分子探针
2. 小动物活体光学成像与传感分析，即时诊断试剂开发
3. 结合光学成像展开药学相关研究
奖励荣誉和学术任职
上海市科技启明星，2022
博新计划，2018
执教课程与教学成果
科研项目
1) 国家自然科学基金面上项目，基于平面化分子内电荷转移机制的短波红外荧光染料研究，NO. 22378072，2024-2027，主持
2) 国家自然科学基金面上项目，比率型NIR-II荧光探针的构建及其在肿瘤微环境可视化中的研究，NO. 22174023，2022-2025，主持
3) 国家自然科学基金青年项目，近红外二区荧光染料的创制及其在生物影像中的应用研究，NO. 21908030，2020-2022，主持
4) 上海市科委科技计划，跨尺度多维度高时空分辨红外荧光活体成像仪， NO. 20S31903700，2020-2023，主持
5) 中国博士后创新人才支持计//中国博士后科学基金面上资助项目（一等），NO. BX20180063/2018M630398，2018-2020，主持，
代表性论文
1) Qingchun Lan, Peng Yu, Kui Yan, Xiaomin Li, Fan Zhang, Zuhai Lei*, Polymethine Molecular Platform for Ratiometric Fluorescent Probes in the Second Near-Infrared Window, J. Am. Chem. Soc. 2022, 144, 21010-21015. (IF = 15.0，中科院I区top)
2) Xuan Zhao, Junfeng Cheng, Lu Zhang, Baofeng Yun, Kui Yan, Bin Wu, Xiao Liu, Fan Zhang, Zuhai Lei*, Near-Infrared II Emissive Diphenylaminoacridine Based on the Planarized Intramolecular Charge Transfer Mechanism, Cell Rep. Phys. Sci. 2023, 4, 101691. (IF = 8.9，JIF分区I区)
3) Xin Zhang, Ying Chen, Haisheng He, Shangfeng Wang, Zuhai Lei*, Fan Zhang*, ROS/RNS and Base Dual Activatable Merocyanine-Based NIR-II Fluorescent Molecular Probe for in vivo Biosensing, Angew. Chem. Int. Ed., 2021, 60, 26337-26341. (IF = 16.6，中科院I区top)
4) Meng Lv+, Yang Yu+, María E. Sandoval-Salinas+, Jianhua Xu, Zuhai Lei*, David Casanova*, Youjun Yang*, Jinquan Chen*. Engineering Charge Transfer State to Facilitate Spin-orbit Charge Transfer Intersystem Crossing in Spirobis[anthracene]diones. Angew. Chem. Int. Ed., 2020, 59, 22179-22184. (IF = 16.6，中科院I区top)
5) Chong Cao, Hang Yin, Biao Yang, Qi Yue, Guoqing Wu, Meng Gu, Yuwen Zhang, Yang Fan, Xiaoyan Dong, Ting Wang, Cong Wang, Xiao Zhu*, Ying Mao*, Xiao-Yong Zhang*, Zuhai Lei*, Cong Li*, Intra-operative Definition of Glioma Infiltrative Margins by Visualizing Immunosuppressive Tumor-Associated Macrophages, Adv. Sci. 2023, 2304020. (IF = 15.1，中科院I区top)
6) Zuhai Lei, Caixia Sun, Peng Pei, Shangfeng Wang, Dandan Li, Xin Zhang, Fan Zhang*. Stable, Wavelength-Tunable Fluorescent Dyes in the NIR-II Region for In Vivo High-Contrast Bioimaging and Multiplexed Biosensing. Angew. Chem. Int. Ed., 2019, 58, 8166 – 8171. (IF = 16.6，中科院I区top)
7) Zuhai Lei, Xinran Li, Xiao Luo, Jing Zheng, Xuhong Qian, and Youjun Yang*. Bright, stable and biocompatible organic fluorophores absorbing/emitting in the deep near-infrared spectral region. Angew. Chem. Int. Ed., 2017, 56, 2979 – 2983. (IF = 16.6，中科院I区top)
8) Zuhai Lei, Youjun Yang*. A concise colorimetric and fluorimetric probe for Sarin related threats designed via the covalent-assembly approach. J. Am. Chem. Soc., 2014, 136, 6594−6597. (IF = 15.0，中科院I区top)
9) Yunyi Liu, Lu Zhang, Ying Chen, Haitao Sun, Jiajian Chen, Ahmed Mohamed Ei-Toni,Aslam Khan, Zuhai Lei,* and Fan Zhang*, A Reversible NIR-II Ratiometric Fluorescent Probe for Real-Time In Vivo ATP Detection, Adv. Optical Mater. 2023, 230114. (IF = 9.0，中科院I区)
10) Zuhai Lei, Fan Zhang*. Molecular Engineering of NIR-II Fluorophores for Improved Biomedical Detection. Angew. Chem. Int. Ed., 2021, 60, 16294-16308. (IF = 16.6，中科院I区top)
