张兴杰
邮箱：zhangxj (at) ynu.edu.cn
职称：副研究员（硕士生导师）
地址：云南大学呈贡校区，教育部自然资源药物化学重点实验室，1405室
云南省“兴滇英才支持计划”青年人才，副研究员/执业药师。
主要从事抗炎、免疫调节、抗病毒等活性小分子的发现及其药理机制研究。以第一/通讯作者身份发表SCI论文18篇；其中，Nature Index一篇，中科院JCR I区3篇，II区8篇，III区6篇，IV区1篇。获得专利授权2项。累计科研项目经费121万元。2017年获得《执业药师资格证书》。
招收硕士生专业：
药理学、药物分析、药物化学、生物与医药等
教育经历：
2007~ 2014，理学博士，细胞生物学，中国科学院昆明动物研究所
2003~ 2007，理学学士，生命科学与技术基地班，云南大学
工作经历：
2021~ 至今，副研究员，云南大学，药学院/教育部自然资源药物化学重点实验室
2016~ 2021，助理研究员，云南大学，教育部自然资源药物化学重点实验室
2014~ 2016，工程师，云南白药集团，创新研发中心/云南省药物研究所
发表论文：
(1) Liang XX#, Zhang XJ#, Zhao YX, Feng J, Zeng JC, Shi QQ, Kaunda JS, Li XL, Wang WG*, Xiao WL*. Aspulvins A–H, Aspulvinone Analogues with SARS-CoV-2 Mpro Inhibitory and Anti-inflammatory Activities from an Endophytic Cladosporium sp. Journal of Natural Products 2022; 85: 878−887. (中科院JCR Q2)
(2) Zhang JJ, Xu YJ, Li R, Zhang Y, Yue CF, Bi DW, Cheng B, Wu XW, Zhang RH, Zhang XJ*, Li XL*, Xiao WL*. Ainslides A−F, Six Sesquiterpenoids Isolated from Ainsliaea pertyoides and Their NLRP3-Inflammasome Inhibitory Activity. Chemistry & Biodiversity 2022; 19:e202200135. (中科院JCR Q3)
(3) Zhang XJ#, Wang TT#, Pu YK, Zeng L, Zhang RH, Li XL, Ji X*, Xiao WL*. Optimized expression of recombinant human NIMA-related kinase 7 (NEK7) with a higher purity in Escherichia coli. Protein & Peptide Letters 2021; 28(12):1391-1397. (中科院JCR Q4)
(4) Zhang XJ#, Shang K#, Pu YK, Wang Q, Wang TT, Zou Y, Wang YM, Xu YJ, Li XL, Zhang RH, Xiao WL*. Leojaponin inhibits NLRP3 inflammasome activation through restoration of autophagy via upregulating RAPTOR phosphorylation. Journal of Ethnopharmacology 2021; 278:114322. (中科院JCR Q2)
(5) Shi QQ#, Wang TT#, Zhang XJ#, Pu YK, Ji X, Li XL*, Dai XC, Zeb MA, Zhang RH, Xiao WL*. The bioactive limonoids from Toona ciliate as NLRP3 inflammasome inhibitors. Industrial Crops and Products 2021; 167:113533. (中科院JCR Q1)
(6) Shi QQ#, Zhang Y#, Wang TT#, Xiong F, Zhang RH, Li XL, Ji X, Zhang XJ*, Wang WG*, Xiao WL*. Euphopias D–F from Euphorbia L.: quantum chemical calculation-based structure elucidation and their bioactivity of inhibiting NLRP3 inflammasome activation. Organic Chemistry Frontiers 2021; 8(12):3041-3046. (中科院JCR Q1)
(7) Shi QQ#, Zhang XJ#, Wang TT#, Zhang Y, Zeb MA, Zhang RH, Li XL*, Xiao WL*. Toonaones A-I, limonoids with NLRP3 inflammasome inhibitory activity from Toona ciliata M. Roem. Phytochemistry 2021; 184:112661. (中科院JCR Q2)
(8) Ni DX#, Wang Q#, Li YM#, Cui YM, Shen TZ, Li XL*, Sun HD, Zhang XJ*, Zhang R*, Xiao WL*. Synthesis of nigranoic acid and manwuweizic acid derivatives as HDAC inhibitors and anti-inflammatory agents. Bioorganic Chemistry 2021, 109:104728. (中科院JCR Q2)
(9) Zhang XJ #, Zhong WM #, Liu RX #, Wang YM, Luo T, Zou Y, Qin HY, Li XL*, Zhang R*, Xiao WL*. Structurally Diverse Labdane Diterpenoids from Leonurus japonicus and Their Anti-inflammatory Properties in LPS-Induced RAW264.7 Cells. Journal of Natural Products 2020, 83, (9), 2545-2558. (中科院JCR Q2)
(10) Shi QQ#, Zhang XJ #, Wang, TT, Wang Q, Sun TT, Amin M, Zhang RH, Li XL*, Xiao WL*. Euphopias A-C: Three Rearranged Jatrophane Diterpenoids with Tricyclo[8.3.0.0(2,7)]tridecane and Tetracyclo[11.3.0.0(2,10).0(3,7)]hexadecane Cores from Euphorbia helioscopia. Organic Letters, 2020, 22, (20), 7820-7824. (Nature Index, 中科院JCR Q1)
(11) Shi QQ#, Zhang XJ #, Zhang Y, Wang, Q, Amin M, Li Q, Wu XW, Li XL*, Zhang RH, Dai XC, Xiao WL*. Toonaolides A–X, limonoids from Toona ciliata: Isolation, structural elucidation, and bioactivity against NLRP3 inflammasome. Bioorganic Chemistry 2020, 105, 104363. (中科院JCR Q2)
(12) Pu DB#, Zhang XJ #, Bi DW, Gao JB, Yang Y, Li XL*, Lin J, Li XN, Zhang RH, Xiao WL*. Callicarpins, Two Classes of Rearranged ent-Clerodane Diterpenoids from Callicarpa Plants Blocking NLRP3 Inflammasome-Induced Pyroptosis. Journal of Natural Products, 2020, 83, (7), 2191-2199. (中科院JCR Q2)
(13) Du BW#, Zhang XJ #, Shi N#, Peng T, Gao JB, Azimova B, Zhang R, Pu DB, Wang C, Abduvaliev A, Rakhmanov A, Zhang GL, Xiao WL*, Wang F*. Luteolin-7-methylether from Leonurus japonicus inhibits estrogen biosynthesis in human ovarian granulosa cells by suppression of aromatase (CYP19). European Journal of Pharmacology 2020; 879:173154. (中科院JCR Q3)
(14) Wang Y#, Lin J#, Wang Q #, Shang K, Pu DB, Zhang RH, Li XL, Dai XC, Zhang XJ*, Xiao WL*. Clerodane diterpenoids with potential anti-inflammatory activity from the leaves and twigs of Callicarpa cathayana. Chinese Journal of Natural Medicines 2019, 17, (12), 953-962. (中科院JCR Q3)
(15) Li Q#, Wu XW#, Wang Q#, Sun TT, Shi QQ, Cheng B, Gong S, Zhang Y, Yue CF, Xiong F, Zhang XJ*, Zhang R*, Xiao WL*. Diterpenoids from Callicarpa rubella and their in vitro anti-NLRP3 inflammasome activity. Fitoterapia 2020, 147, 104774. (中科院JCR Q3)
(16) Wu XW#, Wang Q#, Li Q#, Cui YM, Pu YK, Shi QQ, Bi DW, Zhang JJ, Zhang RH, Li XL*, Zhang XJ*, Xiao WL*. Rubellawus A-D, Four New Diterpenoids Isolated from Callicarpa rubella and Their Anti-NLRP3 Inflammasome Effects. Chemistry & Biodiversity 2020, 17, (12), e2000798. (中科院JCR Q3)
(17) Gao JB#, Zhang XJ #, Shang K#, ZhongWM, Zhang RH, Dai XC, Li XL*, Wang Q, Zou Y, Xiao WL*. Anti-NLRP3 inflammasome abietane diterpenoids from Callicarpa bodinieri and their structure elucidation. Chinese Chemical Letters 2020, 31, (2), 427-430. (中科院JCR Q2)
(18) Zhang XJ #, Wang RR#, Chen H, Luo RH, Yang LM, Liu JP, Sun HD, Zhang HB, Xiao WL*, Zheng YT*. SJP-L-5 inhibits HIV-1 polypurine tract primed plus-strand DNA elongation, indicating viral DNA synthesis initiation at multiple sites under drug pressure. Scientific Reports 2018, 8(1):2574. (中科院JCR Q3)
注：#第一作者，*通讯作者
主持基金项目：
(1) 云南省“兴滇英才支持计划”，青年人才专项项目；
(2) 国家自然科学基金委，地区项目；
(3) 云南省科技厅，面上项目；
(4) 云南省科技厅，青年项目；
(5) 云南省教育厅，教师类项目；
(6) 云南大学，校级项目；
(7) 教育部自然资源药物化学重点实验室，开放基金；
(8) 深圳大学，开放基金。
