Xu Ji
Ph.D, Professor of Pharmacology
Office: Chemistry Building 315
Email:jixu@ynu.edu.cn
Address: Key Laboratory of Medicinal Chemistry for Natural Resource,
Ministry of Education, Yunnan University,
2 North Cuihu Road, Kunming, Yunnan, 650091, P. R. China
Brief Introduction
Professor, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming, Yunnan, China. (2019 - present)
Professor, State Key Laboratory of Phytochemisty and Plant Resources in Southwest China, Kunming Institute of Botany, Chinese Academy of Sciences, China. (2013.3 – 2018.12)
Research Scientist, Department of Genomic Medicine, National Cerebral and Cardiovascular Center, Japan. (2008.4–2013.2)
Ph.D. in Human and Environmental Studies, Graduate School of Human and Environmental Studies, Kyoto University, Japan. (2005 - 2008)
M.S. in Human and Environmental Studies, Graduate School of Human and Environmental Studies, Kyoto University, Japan. (2003 - 2005)
B.S. in Pharmaceutical Analysis, School of Pharmacy, China Pharmaceutical University, China. (1998 - 2002)
Research Interests: Pharmacology and Pathology
Main interests: 1) Screening and developing new drug for treatment of cerebral and cardiovascular diseases from the natural product library; 2) Investigating inflammatory mechanism in hypertension and renal injury, discovering new drug; 3) Studying the function of plasma microRNA as a biomarker of myocardial injury and cerebral infarction.
Foundation and Projects
1. The role of purinergic P2X4 receptor in salt-sensitive hypertension and renal injury, NSFC 81300609, (2014.1-2016.12), responsible
2. Application enlargement of pirfenidone, an existing drug, for renal hypertension and heart failure. Japan Science and Technology Agency (JST)，Adaptable and seamless technology transfer program through target-driven R&D (AS232Z02131G，2011.1-2012.12), responsible
Representative Publications
1. Fan M, Chen X, Wu X, Shao L, Ji X*, Zhao Q*,. Salvifarinin A, a neo-clerodane diterpenoid with a 6/5/7 tricyclic skeleton from Salvia farinacea.Tetrahedron Letters.2018;59:3065-3068.
2. Li H, Chen X, Luo D, Fan M, Zhang Z, Peng L, Wu X, Li R*, Ji X*, Zhao Q*,. Protostane-Type Triterpenoids from Alisma orientale。Chemistry&Biodiversity. 2017;14:e1700452.
3. Li Y, Luo D, Chen X, Li J, Yan L, Li T, Zhao Y, Liu H, Ji X*,Ma X*,. Involvement of arachidonic acid metabolites pathway and nicotinic acetylcholine receptors (nAChRs) on nicotine-induced contractions (or relaxations) in the basilar artery. International Journal of Pharmacology. 2017;13:1-10.
4. Wu X, Luo D, Tu W, Deng Z, Chen X, Su J, Ji X*, Zhao Q*,. Hypophyllins A-D, Unprecedented Labdane-type Diterpenoids with Vasorelaxant Activity from Hypoestes phyllostachya ‘Rosea’. Organic Letter. 2016;18:6484-6487.
5. Long H, Luo D, Yang Y, Zhang L, Pu D, Li J, Chen X, Zhu X, Liu S, Gao J, Wang Y, Ji X*, Xiao W*,. Two new phenolic compounds from the seeds of Machilus yunnanensis. J Asian Nat Prod Res.2016;18:952-958.
6. Naito Y, Ji X, Tachibana S, Aoki S, Furuya M, Tazura Y, Miyazawa D, Harauma A, Moriguchi T, Nagata T, Iwai N, Ohara N. Effects of arachidonic acid intake on inflammatory reactions in dextran sodium sulphate-induced colitis in rats. Br J Nutr. 2015;3:1-12.
7. Weng H, Ji X, Endo K, Iwai N. Pex11a Deficiency Is Associated With a Reduced Abundance of Functional Peroxisomes and Aggravated Renal Interstitial Lesions. Hypertension. 2014;64:1054-1060.
8. Ji X*, Naito Y, Weng H, Ma X, Endo K, Kito N, Yanagawa N, Yu Y, Li J, Iwai N. Renoprotective mechanisms of pirfenidone in hypertension-induced renal injury: through anti-fibrotic and anti-oxidative stress pathways. Biomed Res. 2013;34:309-319.
9. Ji X*, Trandafir CC, Wang A, Kurahashi K. Effects of the experimental subarachnoid hemorrhage on the eicosanoid receptors in nicotine-induced contraction of the rat basilar artery. J Stroke Cerebrovasc Dis. 2013;22:1258-1262.
10. Ji X, Naito Y, Weng H, Endo K, Ma X, Iwai N. P2X7 deficiency attenuates hypertension and renal injury in deoxycorticosterone acetate (DOCA)-salt hypertension. Am J Physiol Renal Physiol.2012;303:F1207-1215.
11. Ji X, Naito Y, Hirokawa G, Weng H, Hiura Y, Takahashi R, Iwai N. P2X7 receptor antagonism attenuates the hypertension and renal injury in Dahl salt-sensitive rats. Hypertens Res. 2012;35:173-179.
12. Ji X, Takahashi R, Hiura Y, Hirokawa G,Fukushima Y, Iwai N. Plasma miR-208 as a biomarker of myocardial injury. Clin Chem. 2009;55:1944-1949.
