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Full Professor Master Advisor |
Office: Chemistry Building 413 |
Tel.: 86-(0)871-65031119 |
Email: yphe@ynu.edu.cn |
Address: School of Chemical Science and Technology, Yunnan University, 2 North Cuihu Road, 650091 Kunming, P.R.China |
Brief Introduction
Full Professor, Yunnan University (2011 - )
Visiting Scientist, University of Wisconsin-Milwaukee (2013 - 2014)
Associate Professor, Yunnan University (2005 - 2011)
Lecturer,Yunnan University (2004 - 2005)
Ph.D., Fudan University (2000 - 2004)
M.S., Yunnan University (1997 - 1999)
B.S., Yunnan University (1990 - 1994)
Research Interests
Computer aided drug design, H (e.g. IV-RT inhibitors, HCV NS5B polymerase inhibitors, anti-cancer drugs), organic synthesis, Structure activity relationship (SAR) research,
Foundation and Projects
NSFC 21262044 (2013 - 2016), responsible
NSFC 30960459 (2010 - 2012), responsible
NSFC 30560179 (2006 - 2008), responsible
National major drug discovery project(2014-2016), responsible
Representative Publications
1.Wu,D.; Feng,Y.; Wang, H.; Yang, J.-F.; Chen, X.; Wang, Y.-P.; Lai, C.-C.; hang, Y.-F.; Li, C.; Xia, X.-S.; He, Y.-P.“Synthesis and biological evaluation of novel anti-hepatitis Cvirus(HCV) agents: 2-hydroxylphenethyl sulfanyl-oxopyrimidines”，Med Chem Res，2017， 26:1388–1396
2.Wang, Z.-H.; Chen, X.; Zhang, Y.-F.; Wang,Y.-P., He,Y.-P.*HQSAR study and molecular design of benzimidazole 5-carboxylicderivatives of hepatitis C virus NS5B polymerase. Scientia Sinica Chimica，2017，47（3）：350-360.
3.Zhang,X.-J.; Lu, L.-H.;Wang,R.-R.; Wang, Y.-P.; Luo,R.-H.; Lai, C.-C. Yang,L.-M.;He, Y.-P. *; Zheng,Y.-T.* DB-02, a C-6-Cyclohexylmethyl Substituted Pyrimidinone HIV-1 Reverse Transcriptase Inhibitor with Nanomolar Activity, Displays an Improved Sensitivity against K103N or Y181C Than S-DABOs, PLOS ONE，2013，11（8）:1~ 11.
3.Wu, D.-C.; Zhuang D.M., Liu X.F., Lu L.H., Wang H., Li C., Lai C. C., Li, J.Y., He Y.P. *，Synthesis and BiologicalEvaluation of Novel Hydroxylphenethyl-S-DACOs as High Active Anti-HIV Agents ，Letters in Drug Design &Discovery，2013，10：271-276.
4.He, Y.-P. *; Long，J.; Zhang，S.-S.; Li，C. ; Lai，C. C.; Zhang，S.; Li，D.-X.; Zhang，D.-H.H. Wang，Cai，Q.-Q.; Zheng，Y.-T. Synthesis and biological evaluation of novel dihydro-aryl/alkylsulfanyl-cyclohexylmethyl -oxopyrimidines (S-DACOs) as high active anti-HIV agents，Bio. Med. Chem. Lett.，2011，21（2）：694-697.
Patents
1.He, Y.-P.; Zheng, Y.-T.;Li,C. et. al, The synthesis Methods and Application of 6-Cyclohexylmethyl Substituted S-DABO Analogues，ZL 200710066433.7, 2010.11.7
2.He，Y.-P. ; Zhuang, D.-M.; Cai,Q.-Q. et. al, The synthesis Methods and Application of N-(4-(cyclohexylmethyl)-5-ethyl-6-oxo-1,6-dihydropyrimidin-2-yl)-2-phenylacetamide, ZL 201110163552.0, 2013.6.19
3.Y.P. He，Xia Xue-Shan, Wu Dao-Chun, et. al,，The synthesis Methods and Application of 5-alkyl-6-(cyclohexylmethyl)-2-((2-hydroxy-2-phenylethyl)thio)-lpyrimidin-4(3H)-one，
ZL 201110358811.5, 2014.4.16
4.Wang, Y.-P.; He,Y.-P.; Liu, X.-F., Yao, Y.;The synthesis Methods and Application of 2- (4- alkyl methanoyl-phenyl-carbonyl-methylthio) pyrimidinone,ZL 201210010392. 2014.12,
5.Wang, Y.-P.; Yan, W.-L.; Guo, Q.; He,Y.-P.The synthesis Methods and Application ofN -phenyl-2 [(1-benzenesulfonyl-1H-benzo [d]imidazole-2-yl) )sulfydryl] acetamide derivatives and its preparation and use.ZL 2012101414.5, 2014.11
APPOINTMENTS & POSITIONS (填写主要社会/科研职位)
1.Deputies to the 12th National People's Congress
2."Light talents of the west" of Chinese academy of sciences，2013
3."Leader of youth academic and scientific technology" in yunnan province，2015
4.The 14th editorial board of the《Chinese Journal of Pharmaceuticals》
