Copper-catalyzed amination of an α-C(sp3)–H bond in inactivated ethers to synthesize α-aminonitriles
By: Zaifeng Yuan, Chunyu Zhu, Zhixian Ma and Chengfeng Xia
Key Laboratory of Medicinal Chemistry for Natural Resources (Ministry of Education and Yunnan Province), School of Chemical Science and Technology, Library of Yunnan University, Yunnan University, 2 North Cuihu Road, Kunming 650091, China
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, 132 Lanhei Road, Kunming 650201, China
CHEMICAL COMMUNICATIONS
Volume: 54 Issue: 78 Pages: 11033-11036
DOI: 10.1039/c8cc06111d
Published:OCT 7 2018
Document Type:Article
Abstract
A copper-catalyzed functionalization of inert cyclic ethers was developed to provide α-aminonitriles via a cascade oxidation/amination/ring-opening/cyanation reaction. A series of highly versatile α-aminonitriles were obtained from primary or secondary anilines, and heterocyclic and aliphatic amines with high yields. This process features excellent functional group tolerance, a broad substrate scope, and high activity under ambient conditions.
全文链接：https://pubs.rsc.org/en/Content/ArticleLanding/2018/CC/C8CC06111D#!divAbstract
