赵云丽
邮箱：zhaoyunli@ynu.edu.cn
职称：副研究员，硕士研究生导师
团队：天然产物研究与应用转化罗晓东教授团队
地址：云南昆明呈贡区大学城东外环南路云南大学化学楼5楼
教育及工作经历
2006年昆明医科大学药学系获理学学士，2011年云南中医药大学获医学硕士学位，2019年云南农业大学获农学博士学位，先后于云南省药物研究所和中国科学院昆明植物研究所从事天然产物研究与应用开发工作，2020.9进入云南大学教育部自然资源药物化学重点实验室。
研究领域和兴趣
天然产物药理毒理研究
研究兴趣：从天然产物中发现具有较好药理活性和成药性的分子，并进行新药的创制与开发。
研究成果
针对因呼吸系统疾病临床上采用抗生素和激素治疗而导致诸多严重的不良反应，从天然产物中寻找和开发高效低毒的对抗呼吸系统疾病的药物，参与新药“灯台叶总生物碱胶囊”的研发，获得CFDA颁发的临床批件，并完成Ⅱ期临床研究。以第一/通讯作者在J Agric Food Chem、Phytomedicine、J Ethnopharmacol、Life Sci、Org Lett等国际著名期刊发表研究论文20多篇，获得国际授权发明专利一项，国内专利多项。
代表性论文
1. Zhao, Y.L.#, Pu, S.B.#, Qi, Y., Wu, B.F., Shang, J.H., Liu, Y.P., Hu, D., Luo, X.D.*, 2021. Pharmacological effects of indole alkaloids from Alstonia scholaris (L.) R. Br. on pulmonary fibrosis in vivo. J. Ethnopharmacol. 267, 113506.
2. Zhao, Y.L.#, Yang, Z.F.#, Wu, B.F., Shang, J.H., Liu, Y.P., Wang, X.H.*, Luo, X.D.*, 2020. Indole alkaloids from leaves of Alstonia scholaris (L.) R. Br. protect against emphysema in mice. J. Ethnopharmacol. 259, 112949.
3. Zhao, Y.L.#, Su, M.#, Shang, J.H.#, Wang, X., Njateng, G.S.S., Bao, G.L., Ma, J., Sun, Q.D., Yuan, F., Wang, J.K.*, Luo, X.D.*, 2020. Acute and chronic toxicity of indole alkaloids from leaves of Alstonia scholaris (L.) R. Br. in mice and rats. Nat Prod Bioprospect 10(2), 77-88.
4. Zhao, Y.L.#, Yang, X.W.#, Wu, B.F., Shang, J.H., Liu, Y.P., Zhi, D., Luo, X.D.*, 2019. Anti-inflammatory Effect of Pomelo Peel and Its Bioactive Coumarins. J. Agric. Food Chem. 67(32), 8810-8818.
5. Zhao, Y.L.#, Yang, Z.F.#, Shang, J.H., Huang, W.Y., Wang, B., Wei, X., Khan, A., Yuan, Z.W., Liu, Y.P., Wang, Y.F., Wang, X.H.*, Luo, X.D.*, 2018. Effects of indole alkaloids from leaf of Alstonia scholaris on post-infectious cough in mice. J Ethnopharmacol 218, 69-75.
6. Zhao, Y.L.#, Cao, J. #, Shang, J.H., Liu, Y.P., Khan, A., Wang, H.S., Qian, Y., Liu, L., Ye, M.*, Luo, X.D.*, 2017. Airways antiallergic effect and pharmacokinetics of alkaloids from Alstonia scholaris. Phytomedicine. 27, 63-72.
7. Zhao, Y.L.#, Shang, J.H., Pu, S.B., Wang, H.S., Wang, B., Liu, L., Liu, Y.P., Mei, S.H.*, Luo, X.D.*, 2016. Effect of total alkaloids from Alstonia scholaris on airway inflammation in rats. J. Ethnopharmacol. 178, 258-265.
8. Gou, Z.P.#, Zhao, Y.L.#, Zou, L.L., Wang, Y., Shu, S.Q., Zhu, X.H., Zheng, L., Shen, Q., Luo, Z., Miao, J., Wang, Y.S., Luo, X.D.*, Feng, P.*, 2021. The safety and tolerability of alkaloids from Alstonia scholaris leaves in healthy Chinese volunteers: a single-centre, randomized, double-blind, placebo-controlled phase I clinical trial. Pharm. Biol. 59(1), 484-493.
9. Hu, B.Y.#, Zhao, Y.L.#, Xiong, D.S., He, Y.J., Zhou, Z.S., Zhu, P.F., Wang, Z.J., Wang, Y.L., Zhao, L.X.*, Luo, X.D.*, 2021. Potent Antihyperuricemic Triterpenoids Based on Two Unprecedented Scaffolds from the Leaves of Alstonia scholaris. Org. Lett. 23, 4158-4162.
10. Liu, W.L., Wu, B.F., Shang, J.H., Zhao, Y.L.*, Huang, A.X.*, 2020. Moringa oleifera Lam Seed Oil Augments Pentobarbital-Induced Sleeping Behaviors in Mice via GABAergic Systems. J. Agric. Food Chem. 68(10), 3149-3162.
11. Wang, M.Y.#, Shen, C.#, An, M.F.#, Xie, C.Q., Wu, X., Zhu, Q.Q., Sun, B., Huang, Y.P., Zhao, Y.L.*, Wang, X.J.*, Sheng, J.*, 2018. Combined treatment with Dendrobium candidum and black tea extract promotes osteoprotective activity in ovariectomized estrogen deficient rats and osteoclast formation. Life Sci 200, 31-41.
